San Francisco 49ers
| Date | Matchup | Result |
|---|---|---|
| 2025-08-10 | vs  Denver Broncos | 9-30 L |
| 2025-08-16 | @  Las Vegas Raiders | 19-22 W |
| 2025-08-24 | vs  Los Angeles Chargers | 30-23 W |
| 2025-09-07 | @  Seattle Seahawks | 13-17 W |
| 2025-09-14 | @  New Orleans Saints | 21-26 W |
| 2025-09-21 | vs  Arizona Cardinals | 16-15 W |
| 2025-09-28 | vs  Jacksonville Jaguars | 21-26 L |
| 2025-10-03 | @  Los Angeles Rams | 23-26 W |
| 2025-10-12 | @  Tampa Bay Buccaneers | 30-19 L |
| 2025-10-20 | vs  Atlanta Falcons | 20-10 W |
| 2025-10-26 | @  Houston Texans | 26-15 L |
| 2025-11-02 | @  New York Giants | 24-34 W |
| 2025-11-09 | vs Los Angeles Rams | 26-42 L |
| 2025-11-16 | @ Arizona Cardinals | 22-41 W |
| 2025-11-25 | vs  Carolina Panthers | 20-9 W |
| 2025-11-30 | @  Cleveland Browns | 8-26 W |
| 2025-12-14 | vs  Tennessee Titans | 37-24 W |
| 2025-12-23 | @  Indianapolis Colts | 27-48 W |
| 2025-12-29 | vs  Chicago Bears | 42-38 W |
| 2026-01-04 | vs Seattle Seahawks | 3-13 L |
| 2026-01-11 | @  Philadelphia Eagles | 19-23 W |
| 2026-01-18 | @ Seattle Seahawks | 41-6 L |
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