| Sincere McCormick | Active | McCormick signed a one-year deal with the 49ers on Wednesday. | 2026-06-10 |
| George Kittle | Questionable | Achilles | 2026-06-04 |
| Mike Evans | Active | Evans is making a strong impression at voluntary OTAs and feels rejuvenated after an injury-plagued 2025, Matt Barrows of The Athletic reports. | 2026-06-04 |
| Mac Jones | Questionable | Undisclosed | 2026-06-04 |
| Brandon Aiyuk | Out | Knee - ACL + MCL | 2026-06-03 |
| Ashtyn Davis | Active | The 49ers signed Davis on Tuesday. | 2026-06-03 |
| Christian McCaffrey | Active | McCaffrey said after Thursday's OTAs that he's looking forward to sustaining another heavy workload in 2026, and that any reductions in touches should come in p | 2026-05-29 |
| Darrick Forrest | Injured Reserve | Undisclosed | 2026-05-29 |
| Nick Bosa | Questionable | Knee - ACL | 2026-05-29 |
| Isaac Guerendo | Questionable | Pectoral | 2026-05-29 |
| Jacob Cowing | Active | Cowing (hamstring) is participating in the 49ers' OTAs, Matt Maiocco of NBC Sports Bay Area reports. | 2026-05-28 |
| Jordan James | Active | James "seems the most likely" of San Francisco's running backs behind Christian McCaffrey to earn the No. 2 role for the upcoming campaign, Nick Wagoner of ESPN | 2026-05-22 |
| Kurtis Rourke | Active | Rourke (knee) will participate in rookie minicamp starting Friday, David Lombardi of SFStandard.com reports. | 2026-05-07 |
| De'Zhaun Stribling | Active | The 49ers' selection of Stribling at No. 33 overall in the 2026 NFL Draft was partially motivated by the organization's strong belief in his personality, leader | 2026-05-07 |
| Kaelon Black | Active | Black is set to compete with recent draft picks Jordan James and Isaac Guerendo for backup touches behind Christian McCaffrey, Grant Gordon of NFL.com reports. | 2026-05-04 |
| Patrick McMorris | Active | The 49ers signed McMorris to a one-year deal Tuesday, Adam Schefter of ESPN reports. | 2026-04-29 |
| Khalil Dinkins | Active | The 49ers signed Dinkins as an undrafted free agent Sunday. | 2026-04-26 |
| Will Pauling | Active | The 49ers signed Pauling as an undrafted free agent Sunday. | 2026-04-26 |
| Wesley Grimes | Active | The 49ers signed Grimes as an undrafted free agent Sunday. | 2026-04-26 |
| Enrique Cruz Jr. | Active | The 49ers selected Cruz in the fifth round of the 2026 NFL Draft, 179th overall. | 2026-04-25 |
| Jaden Dugger | Active | The 49ers selected Dugger in the fifth round of the 2026 NFL Draft, 154th overall. | 2026-04-25 |
| Ephesians Prysock | Active | The 49ers selected Prysock in the fourth round of the 2026 NFL Draft, 139th overall. | 2026-04-25 |
| Carver Willis | Active | The 49ers selected Willis in the fourth round of the 2026 NFL Draft, 127th overall. | 2026-04-25 |
| Gracen Halton | Active | The 49ers selected Halton in the fourth round of the 2026 NFL Draft, 107th overall. | 2026-04-25 |
| Romello Height | Active | The 49ers selected Height in the third round of the 2026 NFL Draft, 70th overall. | 2026-04-25 |
San Francisco 49ers